https://www.smeetonlab.com/research daily 0.75 2023-07-26 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/33f46a85-dbcc-4e95-8892-0400ea84863a/HRHR+NIA+final+graphic.jpeg Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1596212915246-8T9VVKZDO73PKT4WHD4C/nidcr-logo-3.jpg Research https://www.smeetonlab.com/home daily 1.0 2022-12-16 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1595520709270-D95HBYPMZLLE0T5TC1PZ/Wt%2Bdissection%2Bin%2Bfocus.jpg Home - Our Research We use state-of-the-art single cell genomics technologies and zebrafish models to understand how joint cells are specified and how they can be regenerated by stem cells following injury. https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1596209967448-6G4S4J5XR7LS1O2HDLPF/Unknown.png Home - Join Us Our research team is growing. If you’re passionate like we are about science and discovery, we want to hear from you! https://www.smeetonlab.com/contact daily 0.75 2024-10-30 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1596052564725-QQOFLOLF972W5VX0QEWI/20200728_100311.jpg Contact - The Smeeton Lab is part of the Columbia Stem Cell Initiative (CSCI) in the Columbia University Irving Medical Center in Manhattan, New York. Follow us on Bluesky @smeetonlab.bsky.social on Twitter @smeetonlab Follow CSCI on Twitter @CSCIColumbia https://www.smeetonlab.com/publications daily 0.75 2025-10-10 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/3f44923d-6ad0-49d7-952f-423483929252/zebrabow+56dpjr.png Publications - Dynamic cell fate plasticity and tissue reintegration drive functional adult synovial joint regeneration after complete resection Blumenkrantz et al, Nature Communications (2025) https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/18dae1f7-f7e3-4312-8f38-fb3d0330c384/Figure+1_scaledDown_lowRes.png Publications - Ligament injury in adult zebrafish triggers ECM remodeling and cell dedifferentiation for scar-free regeneration Anderson and Mo et al, npj Regenerative Medicine (2023) https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/fba3a9ed-1bd0-4e72-9810-dcfbc7737e0c/JJ+Regeneration+Figure+1.jpg Publications Regeneration of jaw joint cartilage in adult zebrafish Smeeton et al, Frontiers in Cell and Developmental Biology (2022) https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/a341aa4a-deff-4666-aabc-8749efbfa5d3/Figure+1+single+cell+sequencing.png Publications - Lifelong single-cell profiling of cranial neural crest diversification in zebrafish Fabian et al, Nature Communications (2022) https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1613670136383-BT6QVKJ31P99QWJZ4K1E/image-asset.jpeg Publications Zebrafish model for spondylo-megaepiphyseal-metaphyseal dysplasia reveals post-embryonic roles of Nkx3.2 in the skeleton Smeeton et al, Development (2021) https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1603470189033-2QVXZMP33M0264IFIWCY/F4.large.jpg Publications - Lineage analysis reveals an endodermal contribution to the vertebrate pituitary Fabian et al, Science (2020) https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1601486338355-VPUC0IAPLKG6F438G7JH/annrheumdis-2020-218350-F7.large.jpg Publications Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis Roelofs et al, Annals of the Rheumatic Diseases (2020) https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1596574281171-2UVFS4I922XNB7EULF24/Fig.+7.jpg Publications - nkx3.2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish Miyashita et al, Journal of Experimental Biology (2020) https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1596570913041-GQNZD62WK7KFTDELCN8U/lax_42736_elife-42736-fig3-v2.tif.jpg Publications - Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones Giovannone et al, eLife (2019) https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1596207418983-JGCBI1K741GI37EJKYQJ/lax_16415_elife-16415-fig2-v2.tif.jpg Publications - The ancient origins of lubricated joints Askary, Smeeton et al, eLife (2016) Established zebrafish as a relevant model for arthritis research by demonstrating evolutionary conservation of joint lubrication across bony fish and functional synovial joints in the jaw and fins. https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1596206828901-UCNEWFHNSBSAHN49MRPZ/Screen+Shot+2020-07-31+at+10.46.33+AM.png Publications - Building and maintaining joints by exquisite local control of cell fate Smeeton et al, WIREs Developmental Biology (2016) https://www.smeetonlab.com/links daily 0.75 2020-08-04 https://www.smeetonlab.com/join-us daily 0.75 2025-12-18 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/59c182a9-1c20-47d1-9119-4b6dab4b187e/PXL_20250918_161759986.MP.jpg https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/2ae87a2a-0295-4a54-b786-60c65367d257/2023-01-31+11.20.11.jpg https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/3bb17e8e-76f1-4060-8a5e-6ff94a77eaa9/PXL_20250926_212804173.jpg https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/d7a89a01-1063-4fba-9050-2fd4599b8fba/IMG_5651.jpg https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/c52d6070-08fc-4c0a-976b-7c85a24eddd1/Smeeton+Lab+logo.png https://www.smeetonlab.com/team daily 0.75 2026-01-19 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1595454501506-V0OUN2GXCUSWKOVPX7S4/HEADSHOT_Joanna_Smeeton_02_B.jpeg Team - Joanna Smeeton, PhD Principal Investigator Joanna received her BScH from McGill University, her PhD from the University of Toronto (SickKids), and performed her postdoctoral training in the lab of Gage Crump at the University of Southern California (USC Stem Cell). Joanna is the H. K. Corning Assistant Professor of Rehabilitation Medicine Research. At Columbia, she is affiliated with the Departments of Rehabilitation and Regenerative Medicine as well as Genetics and Development. She is a full member of the Columbia Stem Cell Initiative. jms2504@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/e2b3f6fc-ef73-4c6d-9ebc-9d68143c4170/Des+2023.jpg Team Desmarie Sherwood Technician ds3851@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/e8e1ad59-1408-48a3-b415-a4e39f7922ee/Michelle+2023.jpg Team - Michelle Aude Technician mca2195@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/78bda393-b4dd-496d-86c2-b2d98aa85ab8/Katie+Spack.jpg Team - Katherine Spack Postdoc kas2309@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1629393766746-9V1US8COQ4DPP6I53S29/Columbia_ID_Photo_JM.jpg Team Julia Mo PhD Candidate Julia is a PhD Candidate in Genetics and Development. NIH/NIDCR F31 awardee jm5158@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/f161cb1c-d2bf-47dc-9482-0954839637d7/Maria.jpg Team Maria Blumenkrantz PhD Candidate Maria is a PhD Candidate from the Integrated Program in Cellular, Molecular and Biomedical Studies NSF GRFP awardee mhb2188@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/7ec07d60-e8dc-4c44-876a-1703a79060dd/Everett+Headshot+For+Lab+Website.png Team Everett Weinstein PhD Candidate Everett is a PhD Candidate from the Integrated Program in Cellular, Molecular and Biomedical Studies esw2187@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1400fd0f-9648-49f0-afb8-0f0f98860a0d/Safiyah+Ali.jpg Team Safiyah Ali PhD Candidate Safi is a PhD Candidate in Genetics & Development sta2587@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/ef566f87-471d-4da3-a3b8-e288343294e2/Aishwarya+Rao.jpg Team Aishwarya Rao Undergraduate Student Aishwarya is a Barnard Student asr2243@barnard.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/23a24b49-40cc-4c58-a6a1-001f0b61acd5/Kirie+Frederick+headshot.jpg Team Kirie Frederick Undergraduate Student Kirie is a Columbia Student kzf2104@columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/cf858754-1ba8-4d17-a706-a5ff06a1b93b/Hanna+Chen+headshot.jpg Team Hanna Chen Undergraduate Student Hanna is a Columbia College Student hc3463@columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/e525928b-d067-418f-aade-02091b6db085/Subin+Lee.jpg Team Subin Lee Dental Student Subin is a Columbia College of Dental Medicine Student sl5562@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/324b46ce-61e8-41bc-b388-582170d57ef4/IMG_6182.jpg Team Dr. Anderson’s Thesis Defense party - Sept 2025 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/2e6a0ce7-798b-4308-9b04-2355dfb850c9/Lab+Dec+2024.jpg Team Lab - winter 2024 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/e0151b77-b620-4440-91b6-73460cde9fb0/lab+summer+2024+jump.jpg Team Lab picnic - fall 2024 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/744ad861-5c81-43fd-a4cb-8fa0051c2e4e/IMG_2559.jpg https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/7d69bbec-ff86-49d5-88b9-a8c5f8dfe156/IMG_5592.jpg https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/4638383e-3021-4441-87b1-55b32c460a01/IMG_2547.jpg https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/6fcab155-ea69-4115-9b25-3424540cbb8e/Smeeton+Lab+picnic+2023.jpg Team Lab picnic - summer 2023 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/c4dae19a-c800-4313-97f0-d3816f863b63/summer+2023+undergrads.jpg Team Undergraduate researchers - summer 2023 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/0e8682ed-7e50-4f24-95a3-86a728b946aa/G%26D+2023.jpg Team Happy St. Patrick’s Day - March 2023 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/87abde79-c721-44ba-98fd-01085905ce27/IMG_5849+copy.jpg Team Happy Holidays - December 2022 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/e378826a-a949-49f9-884d-fc8e3212385c/DSC06927a.jpg Team Lab Group - Summer 2022 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/0c3fcc4d-af23-42c2-add0-f727db3e1408/pottery+2022.jpg Team pottery party @ Mugi - summer 2022 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/9c97422f-5ac8-41c3-83d3-2fbe63e05ba4/lab+lunch+062021.jpg Team lab - summer 2021 https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1623362006785-57JVZOXMWR56GH6KIXCY/Lab+Action+Shot+20210610_123333.jpg Team https://images.squarespace-cdn.com/content/v1/5f18868568f6f36cf30738e8/1623362030353-K0HV7GRG1S1UNVZT7YYV/lab+ice+cream+day+2021.jpg Team https://www.smeetonlab.com/store daily 0.75 57935-01-15